1ST ADVANCED COURSE ON THE PHARMACOLOGICAL TREATMENT OF DRUG RESISTANT EPILEPSIES (DRE): FROM RARE TO COMMON EPILEPSIES

Monday, 29th May

DEFINITION, EPIDEMIOLOGY, BASIC MECHANISMS

16:15 h - 16:30 h

Welcome and Introduction

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain
16:30 h - 17:00 h

Epidemiology and social impact of DRE

Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain
17:00 h - 17:30 h

What is DRE? Concept and definitions

Gaetano Zaccara. Azienda Sanitaria di Firenze. Florence, Italy
17:30 h - 18:00 h

Basic mechanisms of drug-resistance

Heidrun Potschka. Ludwig-Maximilians-University. Munich, Germany
18:00 h - 18:30 h

Roundtable and discussion “What is DRE?”

Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain
Heidrun Potschka. Ludwig-Maximilians-University. Munich, Germany
Gaetano Zaccara. Azienda Sanitaria di Firenze. Florence, Italy
Tuesday, 30th May

FOCAL EPILEPSIES

08:30 h - 09:00 h

Can we predict DRE early in the focal epilepsies?

Matthew Walker. UCL Queen Square Institute of Neurology. London, United Kingdom
09:00 h - 09:30 h

Can we avoid DRE with early interventions?

Elinor Ben-Menachem. Sahlgrenska Academym University of Gothenburg. Gothenburg, Sweden
09:30 h - 10:00 h

Optimal pharmacological treatment of DRE

Felix Rosenow. Epilepsy Center Frankfurt Rhine-Main. Center of Neurology and Neurosurgery, Goethe-University Frankfurt. Frankfurt, Germany
10:00 h - 10:30 h

Discussion

10:30 h - 11:00 h

Break

11:00 h - 12:00 h

Symposium Angelini. Time is life in epilepsy: Can we aim higher with cenobamate?

Chairman: Manuel Toledo Argany

Welcome and introduction to Time is Live in Epilepsy

Speaker: Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain

The twin traps of overtreatment and therapeutic nihilism in drug resistant epilepsy

Speaker: Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany

Round table: Early use vs late cenobamate use

Speaker: Vicente Villanueva. Hospital Universitario y Politécnico la Fe. Valencia, Spain
Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain
Pavel Klein. Mid-Atlantic Epilepsy and Sleep Center. Bethesda, USA
Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany

Q&A

Speaker: Vicente Villanueva. Hospital Universitario y Politécnico la Fe. Valencia, Spain
Pavel Klein. Mid-Atlantic Epilepsy and Sleep Center. Bethesda, USA
Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain
Bernhard Steinhoff. Neurology and Clinical Neurophysiology, University of Freiburg. Kork Epilepsy Center, Kehl-Kork, Germany

FUTURE ASMs AND THERAPIES

12:00 h - 12:45 h

ASMs under development

Meir Bialer. Institute for Drug Research, School of Pharmacy and David R. Bloom Centre for Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem. Jerusalem, Israel
12:45 h - 13:30 h

Future therapies

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
13:30 h - 14:30 h

Lunch

IDIOPATHIC GENERALIZED AND AUTOIMMUNE EPILEPSIES

14:30 h - 15:00 h

Drug resistant IGEs: clinical characteristics

Javier Salas Puig. Hospital Universitario Vall d'Hebron. Barcelona, Spain
15:00 h - 15:30 h

Treatment of drug resistant IGEs

Christoph P Beier. Department of Neurology and Neurophysiology, Odense University Hospital & Svendborg Hospital. Odense, Denmark
15:30 h - 16:00 h

Treatment of autoimmune epilepsies

Mar Carreño. Hospital Clínic. Barcelona, Spain
16:00 h - 16:30 h

Discussion

Wednesday, 31st May

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHIES (DEEs)

08:30 h - 09:00 h

Clinical characteristics of the main types of DEEs

Elena Gardella. Danish Epilepsy Center and University of Southern Denmark. Dianalund, Denmark
09:00 h - 09:30 h

Treatment of Dravet disease and Lennox-Gastaut syndrome

Vicente Villanueva. Hospital Universitario y Politécnico la Fe. Valencia, Spain
09:30 h - 10:00 h

Treatment of other DEEs

Stephan Auvin. Robert Debré Hospital, Public Hospital Network of Paris. Paris, France
10:00 h - 10:30 h

Break

10:30 h - 11:30 h

Symposium UCB. Beyond seizure management in DEEs

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
Patricia Smeyers. Hospital Universitario y Politécnico La Fe. Valencia, Spain
Vicente Villanueva. Hospital Universitario y Politécnico la Fe. Valencia, Spain

SPECIAL LECTURE

11:30 h - 12:15 h

Comorbidities, mortality, and SUDEP in DRE

Torbjörn Tomson. Department of Clinical Neuroscience, Karolinska Institutet. Stockholm, Sweden
12:15 h - 12:45 h

Comprehensive evaluation test

12:45 h - 13:00 h

Conclusions and awards

Jose M Serratosa Fernández. Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain
Manuel Toledo Argany. Hospital Universitario Vall d'Hebron. Barcelona, Spain